学术论文
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- Therapeutic Vaccination with Lentiviral Vector in HBV-Persistent Mice and Two Inactive HBsAg Carriers
- Authors: Yumeng Zhang, Maryline Bourgine, Yanmin Wan, Jieyu Song, Zongying Li, Yiqi Yu, Wangfang Jiang, Mingzhe Zhou, Cuiyuan Guo, Didier Santucci, Xiao Liang, Christian Brechot, Wenhong Zhang, Pierre Charneau, Hong Wu, Chao Qiu
Abstract:
Background & Aims: Immunotherapy for chronic hepat…
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- HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore
- The HIV‐1 central DNA Flap acts as a cis‐acting determinant of HIV‐1 genome nuclear import. Indeed, DNA‐Flap re‐insertion within lentiviral‐derived gene transfer vectors strongly stimulates gene transfer efficiencies. In this study, we sought to understand the mechanisms by which the central DNA Flap mediates HIV‐1 nuclear import. Here, we s...
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- Protective antiviral immunity conferred by a nonintegrative lentiviral vector-based vaccine
- Lentiviral vectors are under intense scrutiny as unique candidate viral vector vaccines against tumor and aggressive pathogens because of their ability to initiate potent and durable specific immune responses. Strategies that alleviate safety concerns will facilitate the clinical developments involving lentiviral vectors. In this respect, the devel...
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- Lentiviral vector-based prime/boost vaccination against AIDS: pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques
- AIDS vaccination has a pressing need for more potent vaccination vectors capable of eliciting strong, diversified, and long-lasting cellular immune responses against human immunodeficiency virus (HIV). Lentiviral vectors have demonstrated efficiency not only as gene delivery vehicles for gene therapy applications but also as vaccination tools. This...
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- Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice
- Over expression of telomerase represents a hallmark of cancer cells and the induction of T cell immunity against this universal tumor antigen have gained promising interest for anticancer immunotherapy. In this study we evaluated a recombinant lentiviral vector expressing the human telomerase reverse transcriptase (lv-hTERT) vaccination in the huma...
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